PNB 2264 Lecture Notes - Lecture 24: Avoidance Speech, Kidney Bean, Angiotensin
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Released into infundubula and travels to pituitary and causes tsh. Largest pure endocrine gland in the human body. Follicles, looks like ping pong balls: hollow structure, surrounded by cells. Epithelium: lumen thyroglobulin, has tyrosine on the surface, hundreds on the surface. Iodine stores in there follicles, 99. 9% of iodine in your body is stored in these follicles. When tsh comes along, the t3 and t4s are cut off and they are fat soluble and they travel into the blood supply. Therefore you wear a jacket in 50 degrees in fall and shorts in 50 degrees in spring. The first cold day in fall you releases t4 which increases metabolism, once it hits that sa(cid:373)e te(cid:373)p i(cid:374) spri(cid:374)g (cid:455)our (cid:373)eta(cid:271)olis(cid:373) has alread(cid:455) adjusted a(cid:374)d (cid:455)ou do(cid:374)"t feel as (cid:272)old. Lack of iodine while in utero causes cretinism severe mental retardation in the absence of iodine. Hypothyroidism (iodine deficiency: fetus retardation, cretinism, adults goiters (in severe cases)