PNB 2265 Lecture Notes - Lecture 2: Haldane Effect, Nfkb1, Hematocrit
27 Jan 2017
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Oxygen binding changes shape (properties of heme can change too) Binding is cooperative: one binding site can influence the other binding sites bc of shape and property changes. Bohr effect: when carbon dioxide binds hb to one chain, this facilitates the release of oxygen from another chain, replenish a tissue"s o(cid:454)(cid:455)gen suppl(cid:455, respiration co2 waste product, favors the release of o2. Haldane effect: deoxygenated hb has a higher affinity for co2, once oxygen off of subunits, it"s easier to pick up co2. Increase in p50 (shift to right), decrease in binding affinity. Shows that binding affinity decreases during conditions that shift the graph to the right. P50 is inversely proportional to binding affinity. Shifting to the left, favors loading of oxygen (higher affinity) (fetal hemoglobin) Shifting to the right causes oxygen to be more readily released to tissues. Shows that p50 value increases when oxygen is more readily released. A failure of the blood to oxygenate tissues.
