PNB 2265 Lecture Notes - Lecture 4: Transferrin, Hemoglobinuria, Biliverdin
27 Jan 2017
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Document Summary
Red blood cells survive for approximately three months inside the body before undergoing apoptosis (cases of trauma) Phagocytosis by macrophages (wbcs: engulf cell and break it down. Breakdown protein components: heme is converted to biliverdin (green) (intermediate), then bilirubin (yellow) Incorporated into digestive secretions and excreted in the liver as bile: degraded/excreted. Abnormal (trauma, hemorrhaging, destroyed more rbcs then you have wbcs to deal with) Hemolysis: hematuria: blood in urine, hemoglobinuria: hb in urine. May lead to a(cid:272)ute tu(cid:271)ular (cid:374)e(cid:272)rosis (kid(cid:374)ey"s (cid:271)e(cid:272)o(cid:373)e da(cid:373)aged fro(cid:373) trying to remove reactive iron from blood circulation and into urine: liver failure. Excessive bilirubin in blood causes skin and sclera to turn yellow (jaundice) Bilirubin does not make it to digestive system to be excreted. Synthetic blood? (cannot just give hemoglobin, need wrapper, do not undergo degradation pathway, often end up in kidney) (particular interest in military) Can kill patient by producing clotting reaction. Donor/recipient compatibility can be predicted from this test.
