PNB 2265 Lecture Notes - Lecture 10: Hydrostatics, Adrenergic Receptor, Tunica Intima

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Increased capillary permeability: blockage of lymph, veins, return blood to heart, low pressure conduit back to right atrium, narrow pressure gradient, highly compliant, this presents a functional problem, adaptation of veins, overcome by, large diameter/lumen. Blood pressure regulation: regulation of mean arterial pressure, map = co * tpr, co = sv * hr, sv = edv esv, major regulatory control of tpr = arteriolar radius. Increased map: hormonal control: fast (respond to decrease in o2, increase in co2, adrenal medulla (fight/flight) (sns, ne (vasoconstrictive, epinephrine, effects of epi, peripheral vasoconstriction (increase tpr, alpha adrenergic receptors on bv. Increase co by decreasing esv: atrial natriuretic peptide (released in response to stretching of atria) Increase map, volume (in atria) anp vasodilation decreased. Map: adh (antidiuretic hormone; vasopressin) (control plasma volume, decrease blood volume and map or increase osmolarity or circulating all. Increase adh water conservation/retention increase map.

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