PNB 2265 Lecture Notes - Lecture 19: Portal Vein, Hepatic Portal System, Acetaldehyde Dehydrogenase

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Digestion: fats: lumen of small intestine, fats are not water soluble, large fat droplets from stomach, non-polar, lipid-soluble, hydrophobic, start with mechanical digestion (motility, peristalsis, segmentation) Absorption: fats: apical membrane, monoglycerides & fatty acids diffusion, cholesterol transporter. Cholesterol + triglycerides + protein in intestinal cell. Removed by the lymphatic system: basolateral membrane, exocytosis. The hepatic portal system: nutrient rich blood from gut , portal vein , liver!, hepatic vein (to vena cava, hepatic portal vein brings everything to liver! (everything you eat, liver metabolism, carbs, amino acids, lipids, detoxification. Phases of integrated meal response: cephalic phase, gastric phase. Primitive animals have two way digestive system (mouth and anus are same), more efficient as you do not need to finish eating before digesting (better for small animals) Humans (larger) this would be inefficient as you would have to wait to eat again until digesting (long time from intestines to mouth), one way digestive tract.

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