PNB 2265 Lecture Notes - Lecture 15: Fluid Compartments, Lightning, Luigi Galvani
11 Sep 2017
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Document Summary
Types of membrane transport: active: in order to move across a membrane, requires energy, carrier-mediated, passive: no energy required, channel-mediated, carrier-mediated. Channel mediated: ion channels: hole/port through membrane, selective about the molecules that they allow passage, principles of selectivity are similar for many different channels, needs to be gradient. Channel categorization: gating (how gate is opened: when voltage gets to starting point: voltage gated, mechanically gated: physical signal. Channelopathies: diseases and disorders that are the result of ion channel dysfunction, proteins can get mutated in response to environmental stimuli, inherit faulty copy of gene. Ligand-gated: signaling molecule from inside or outside cell (hormones) Ion channels depend on pumps, pumps often depend on ion channels as well. Insulin secretion depends on intracellular ligand gated channel. Ttx deadly and delicious: acts as sensory blocker, gets tingling sensation in mouth, can affect heart if not prepared correctly, very specific blocker of very specific channel (sodium channel)
