PNB 2274 Lecture Notes - Lecture 12: Neuromuscular Junction, Sodium Channel, Extracellular Fluid
12 Apr 2018
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Vesicle: once exposed to the cleft, all contents exit, extracellular fluid enters, could reuptake a little of old transmitters. Goldman-hotchman-katz is the expanded ions equation for all ions, based on nernst, V=rt/f*ln(p[ion]), positive ions out in numerator and cl in, opposite for denominator, can usually reduce down to a nernst. Action potentials are all or nothing events, whereas gradient potentials can go in increments, cl permeability ex, could go either way and eventually could lead to action potential or inhibit it. Sodium channels usually closed and unblocked, default state when not firing, positive voltage needed for open and blocking, usually negative! All voltage-gated channels we care about (k, cl, na) opened by + and closed by -. Don t need names of any neuromuscular disorders at all, understand mechanisms and neuromuscular junction, ach release, ca, receptors, potentials, contraction. 2+ on conc, nernst, goldman, so 1/5 of questions. Few on diff between smooth and skeletal ms.
