PSYC 2200 Lecture Notes - Lecture 10: Reuptake, Fluoxetine, Caffeine
Document Summary
Ionotropic receptor: a transmitter receptor ion channel that opens directly when the transmitter binds to it. Metabotropic receptor: transmitter receptor coupled to g-protein that causes a chain of chemical reactions and indirectly alters postsynaptic ion channels and movement ligand/receptor-- substance that binds; receptacle for binding (think key- ligand) to a lock (receptor) Receptor affinity-- how likely the ligand is to bind the receptor, relative to other ligands. Agonist-- receptor promotor (binds and activates receptor, or increases binding affinity of a receptor ligand) Antagonist-- receptor inhibitor (binds and blocks receptor (competetive), binds elsewhere but prevents activation (non-competetive), or decreases binding affinity of a receptor ligand. This is one reason drug users often have to use more drug over time, and/or are unable to achieve the initial high after chronic use (acquired tolerance) Competitive antagonists can fit into the same receptor and bind where the neurochemical wanted to bind, blocking the receptor site but doesn t activate the receptor site.