BME 80H Lecture Notes - Lecture 2: Heredity, Mendelian Inheritance

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Lecture #1- History and Social Impact (chapter 1)
I. History of Genetics
A. The Early Beginnings: pre-Mendel
1. (8000B.C.) Transition from nomadic (hunter-gatherers) to agrarian culture
due to selective breeding of plants and animals.
-Practical understanding only (not molecular) - they understood that you take seeds
from better plants, but not how they were transferred
2. Early ideas on HOW the traits are transmitted:
Hippocrates (400B.C.) On Generation
All parts of the body, particularly the brain, produce substances
"humors" that get collected together to provide the material for
heredity. Humors from the male and female were blended to produce
the offspring
Aristotle (384-322B.C.) argued against Hippocrates' ideas noting that:
-traits skipped generations
-body parts lost in adults (say someone loses a limb) is still present in the
children which goes against this theory, but because he did not propose a
new theory this one stuck
3. (1600s) Preformation hypothesis dominated biology.
-this was the next dominant belief
-tiny preformed human = homunculus
-spermastic was the belief that the tiny human was in the sperm
OR
-oovisitic was the belief that it was found in the egg
-note it cannot be both which is why it was disproven because offspring has traits
from both parents
-reason for this theory was that early microscopes were poor and it looked as
though tiny humans were inside
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Document Summary

Lecture #1- history and social impact (chapter 1: history of genetics, the early beginnings: pre-mendel, (8000b. c. ) Transition from nomadic (hunter-gatherers) to agrarian culture due to selective breeding of plants and animals. Practical understanding only (not molecular) - they understood that you take seeds from better plants, but not how they were transferred: early ideas on how the traits are transmitted: All parts of the body, particularly the brain, produce substances. humors that get collected together to provide the material for heredity. Humors from the male and female were blended to produce the offspring. Aristotle (384-322b. c. ) argued against hippocrates" ideas noting that: Body parts lost in adults (say someone loses a limb) is still present in the children which goes against this theory, but because he did not propose a new theory this one stuck: (1600s) preformation hypothesis dominated biology. Spermastic was the belief that the tiny human was in the sperm.

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