BIPN 100 Lecture Notes - Lecture 15: Calcium Sparks, 1Time Airline, Cyclic Adenosine Monophosphate
11 Apr 2017
School
Department
Course
Professor
Document Summary
Signal conduction through the heart and the electrocardiogram know what happens on each point of the curve first heart sound, cuspid valves shutting; second sound, semilunar valves shutting. Without autonomic control, heart would be beating at 90 beats/min actual heart rate is close to 60 beats/min: parasympathetic. Ach m2 receptor decreases concentration of intracellular messenger camp these are on autorhytmic cells noncontractile (actually muscle cells that lost the ability to contract), sa node. K+ decrease, ca++ increase, hcn channel increase increase ca++, no hcn so no effect phosphorylation of phosphorlamban ca++ pump. Sr will have increased calcium concentration (higher calcium concentration) when calcium channel opened, more is released and more quickly into cytoplasm bigger calcium spark (more forceful contraction) and shorter duration. Signal conduction through the heart and the electrocardiogram. As cardiac contraction shortens, time for filling remains chronotropic- noncontractile, inotropic contractile. Neuronal effect and frank sterling effect can add to each other.
