BIPN 100 Lecture Notes - Lecture 13: Cyclic Adenosine Monophosphate, Purkinje Fibers, Pharmacokinetics

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Cardiac muscle: in between smooth and skeletal muscle, branched cells with single nucleus, connected to other cells with intercalated disks, similarities to skeletal muscles. T-tubules that carry action potentials into core of muscle cells. Mitochondria sarcoplasmic reticulum (calcium store) sarcolemma (membrane) Has (all activated by depolarization: voltage gated sodium channel, voltage gated calcium channels, voltage gated fast k, voltage gated slow k+ When membrane potential goes back to negative the calcium channels close. Na+ channels: ca2+ channel close after membrane potential gets more negative; slow k+ channels open. Purkinje fibers are special fibers that are located in the atrioventricular, or av, bundle of the heart. Their function is to send nerve impulses to the cells in the ventricles of the heart last signal: connecting fibers between the two nodes = internodal fibers, signal travels along noncontractile and contractile fibers. More pressure in system = more flow.

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