BIPN 100 Lecture Notes - Lecture 17: Hypotension, Angiotensin, Distal Convoluted Tubule
16 Dec 2018
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Document Summary
Regulation of k+ secretion and na+ reabsorption in the distal tubule and collecting duct. Steroid hormone (produced in the adrenal cortex of the adrenal gland) Aldosterone acts on principal cells: aldosterone binds cytoplasmic receptor, hormone-receptor complex initiates transcription, protein synthesis of new protein channels and pumps, new proteins modulate existing channels and pumps, increased na reabsorption and k+ secretion. Becomes angiotensin i (which is converted to angiotensin ii by ace) An increase in plasma potassium levels is properly called. Response to high blood pressure: atrial myocytes synthesize and store anp, anp is released when myocytes are stretched by high filling volumes, acts along the length of the collecting duct. Atrial cells in the heart produce a hormone and it is released when the blood pressure is too high (too much stretching) This peptide that is released is anp. Acts along the length of the collecting duct. Released when the atrial cells are stretched.
