BIPN 152 Lecture Notes - Lecture 19: Basal Ganglia, Lrrk2, Catechol-O-Methyl Transferase
1 Aug 2018
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Document Summary
Loss of substantia nigra neurons leads to pd; treatment by replacing dopamine via administration of its precursor l-dopa: essential role in motivation & reward, arousal, activity levels; emesis. Lose substantia nigra da neurons: modulates firing rate of neuron. Missing da neurons, so more thalamus + cortex -> imbalanced flow of information in motor circuit = leads to symptoms of motor circuit: red = inhibitory neurotransmitters, trouble initiating first movement therapies for parkinson"s disease - Increase dopamine by giving l-dopa: give precursor (l-dopa) instead of dopamine because l-dopa can pass the blood brain barrier, while dopamine cannot, deep brain stimulation, dopamine receptors everywhere, so don"t want to generally increase dopamine. Small fraction of cases are hereditary: alpha-synuclein. Finding a gene for parkinson"s disease (alpha-synuclein was found) Family history of pd, then gather genetic information to map where among chromosomes is the gene that is associated with pd. Find mutation in particular gene associated with disease.
