BICD 100 Lecture Notes - Lecture 9: Mendelian Inheritance, Gamete, Meiosis
1 Apr 2019
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Two primary types of alteration in chromosome structure. Extra gene copy is free to mutate, diverge and do something new. However, significant consequences for heterozygotes during gamete formation and thus fertility. Chromosomal segment goes to a new place in the genome. Typically tolerated if break doesn"t occur in the middle of a gene, just rearranges gene order. However, significant consequences for heterozygotes during gamete formation and thus fertility (similar to inversions) Through analysis of these alleles, geneticists gain insight into. Linkage analysis demonstrates gene location by virtue of proximity to other linked genes. Mapping allowed identification of the responsible mutations in cftr. Recent success in using knowledge fo gene to find pharmacological therapies. Modulator drugs now used in patients (with more options in pipeline) If g and w are on different chromosomes, they sort independently week 6 page 1. If g and w are on different chromosomes, they sort independently.
