BICD 100 Lecture Notes - Lecture 11: Dna Profiling, Point Mutation, Wild Type

• School: UCSD
• Department: Biol/Genetics,Cellular & Develop
• Course: BICD 100
• Professor: Deborah Yelon

Document Summary

Part of the definition of a snp (vs. a mutation) Compare dna marker profile in an individual and in a tissue sample. Use microsatellites (also called short tandem repeats or strs) The fbi has selected a core set of 13 strs for codis. Ocme uses dna markers to identify human remains. Has identified remains of 1642 individuals from wtc destruction. Probability calculations based on assumption of a large unrelated population. Profiles are only as reliable as the lab that they come from. Dna profiles are only relevant to the specific piece of evidence involved. Key aspects of the genetic code are relevant to mutations. Unambiguous code - each triplet codes for one amino acid. 3 codoons specify stop - uaa, uag, uga. Degenerate code - some amino acids specified by more than one triple t. Change in a gene that alters or impairs its function. Functional version of a gene found relatively frequently in population.