BICD 100 Lecture Notes - Lecture 13: Genomic Imprinting, Galactose, Operon
1 Apr 2019
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Document Summary
Example of transcriptional regulation through cis-acting and trans-acting factors in eukaryotes. Provides a good analogy to inducible operons in prokaryotes. Three enzymes required for utilization of galactose in yeast. Each of these three genes has its own promoter. What types of mutations could affect gal gene regulation. A mutation that makes gal80p unable to be transported into the nucleus would cause the gal genes to be . Then the gal genes would just always be on. A mutation that makes gal4p unable to bind ot the uas would cause the gal genes to be uninducible by galactose and would be recessive. A mutation that makes gal80p unable to bind to gal4p would cause the gal genes to be constitutively activated and would be recessive. Regulatory sequences are to the sole determinant of transcriptional regulation. Epigenetics: alteration of gene expression without alteration of dna sequences. Sometimes specific genes are only expressed from one parent.
