BICD 110 Lecture Notes - Lecture 9: Chronic Myelogenous Leukemia, Tyrosine-Kinase Inhibitor, Chromosomal Translocation
Document Summary
Inherited cancer susceptibility syndromes need to know: rb+/- : hereditary retinoblastoma. p53+/- : li-fraumeni syndrome. Recurring tumors at multiple organ sites: brca1+/- : hereditary ovarian and breast cancer, brca2 +/- : hereditary ovarian and breast cancer, msh2 +/- : hereditary human non-polyposis colon or mlh1 +/- cancer (hnpcc). Inherited cancer susceptibility syndromes: vhl +/- : von hippel-lindau syndrome. ) activate g1 cdk: expression of cyclin, need to know in each phase, rb keeps cells from dividing by inhibiting e2f, e2f is tf that binds to promoters of genes that encode proteins for. S phase entry to activate cell proliferation: g1cdk phosphorylates rb (inactivates) and frees e2f active. E2f protein cell cycle: cyclin e and a expression + feedback loop to phosphorylate. Inhibit cell proliferation through upregulation of inhibitors of. Aif, smac) signal apoptosis: caspases: proteases, made as zymogen (pro-caspase 3 inactive) //with initatior caspase active caspase 3, tetramer, substrates (what it cuts): inhibitors of apoptosis (icad,
