BIPN 150 Lecture Notes - Lecture 11: Chronic Inflammatory Demyelinating Polyneuropathy, Paraproteinemia, Peripheral Neuropathy
Document Summary
Injury (2/12) (peripheral neuropathy - a result of damage to your peripheral nerves, often causes weakness, numbness and pain, usually in your hands and feet) Cmt4 - recessive mutations: cmt1 - symptoms include muscle weakness, atrophy, and reduced sensation particularly in the feet, lower legs, hands, and forearms. Glial cells: glia are non-neuronal cells of the brain, spinal cord and nervous system. Do not fire action potentials and because of this, we used to think they were not important (each specialized for particular function) Variety of subtypes of glial cells including astrocytes, oligodendrocytes, and microglia. Implicated in synaptic remodeling during development: the importance of schwann cells. Neural crest-derived cells that, in vertebrate animals, form myelin and facilitate the propagation of action potentials along peripheral axons. Winter 2019: also provide axons with energy (lactate, after injury, schwann cells dedifferentiate into repair cells, thereby facilitating axonal regeneration. Schwann cells repair after injury: uninjured nerve initial reaction to injury .
