BIPN 150 Lecture Notes - Lecture 12: Tectospinal Tract, Rubrospinal Tract, Vestibulospinal Tract
Document Summary
Nervous system: 100 billion neurons, 100,000 billion connections. Pns in the developing and adult animal: neuronal growth and sprouting promoters, nerve growth factor (ngf), brain derived neurotrophic factor (bdnf), neurotrophic- Bipn 150: 3 footprint and gait: axonal regeneration vs. axonal sprouting, regeneration: growth from injured axons or axonal branches. Usually for a longer distance over a longer period of time: sprouting: growth from uninjured axons or axonal branches (e. g. uninjured collaterals of injured axons). Usually for a shorter distance: plasticity: in a more specific sense, refers to even more localized anatomical changes , often from uninjured fibers. Inhibition of rho signaling (y-27632, an inhibitor of rock) Good glia: olfactory ensheathing glia: gene transfer via. Injection of rna: retroviruses, antisense oligonucleotides, e. g. Gap-43 transgenic mice show a 60-fold increase in adult drg axon regeneration in peripheral nerve gram in spinal cord, in vivo.
