BIBC 120 Lecture Notes - Lecture 7: Polyunsaturated Fatty Acid, Essential Fatty Acid, Coconut Oil
Document Summary
Fat and lipid consumption are very controversial in its health content. In 2014, thought that eating butter was good: before, thought that eating a fat-free diet was ok to be healthy. If supplemented with linoleic acid (omega-6), but not saturated fa (stearic acid), led to recovery. Therefore, linoleic acid is an essential fatty acid. Fatty acid structure: saturated fatty acid: no double bonds, has methyl end and carboxyl end, count from methyl end, nomenclature: c#:#. In the cytosol, acetyl-coa gains a carboxyl group using the enzyme acetyl-coa carboxylase (acc): creates 3c compound malonyl-coa. This launches fatty acid synthesis: this step is the rate-limiting step, also, the enzyme is the target for regulators of lipid metabolism, when you eat food, insulin is released. Insulin activates acc, allowing fat production to store calories: when you fast, want to use storage pools, so acc is inhibited by ampk and. Involves acyl-carrier protein (acp), nadph, enzymes acc and fas.
