BILD 1 Lecture 11: Cancer and Cancer treatment

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Biology/Lower Division

51817 lecture notes (11) Cancer and Cancer treatment Wednesday, May 17, 2017 2:37 PM Types of cancers determined by tissue of origin Carcinomas arise from epithelial cells that cover external and internal body surfaces (e.g. lung, breast, and colon cancer) Sarcomas develop from supporting tissues such as bone, cartilage, fat and muscle Lymphomas and leukemias arise from cells of lymphatic and blood origin, respectively 23 of mutations in human cancers are left to random chance. Most cancers are not hereditary Most are replicative or environmental Some inherited predispositions to Cancer Tumor predisposition syndromes Gene affected Earlyonset familial breast cancer BRCA1 Familial adenomatous APC Familial melanoma CDKN2 Gorlin syndrome PTCH1 Hereditary nonpolyposis colon cancer MSH2, 6 LiFraumeni syndrome P53 Multiple endocrine neoplasia, type 1 MEN1 Multiple endocrine neoplasia, type 2 NF2 Retinoblastoma RB1 Von HippelLindau syndrome VHL Wilms tumor WT1 For each of these, if you have the allele, it does not mean you will get that cancer. It is based on probability In some cases, those numbers can be very high (BRCA1) Viruses associated with human cancers Virus type Virus name Associated cancers DNA EpsteinBarr virus Burkitts lymphoma, B and T cell lymphomas Viruses Human papilloma virus 16, 18 Cervical cancer Hepatitus herpesvirus8 Heptacocellular Carcinoma Kaposi sarcome, lymphoma
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