BILD 2 Lecture Notes - Lecture 11: Aids, Reverse Transcriptase, Gp41

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36. 7 million with hiv/aids, human immunodeficiency virus, virus that attacks the t-cells of the immune system which help fight off infection. Reduced number of t-cells results in decreased ability to fight off infections and disease: if left untreated, hiv can progress to aids, aids: acquired immunodeficiency syndrome, virus, a pathogen or disease causing microorganisms. They are infectious, spread from host to host, and can evolve over time. Derived from the host cell"s plasma membrane: contains 2 glycoproteins (gp) essential for binding and fusion, gp 120, gp 41: are proteins on membrane responsible for attacking the host cell (helper t cells, matrix. Layer of protein, ensures structural integrity of virus: capsid. Layer of proteins: encapsulates genome and 3 enzymes, reverse transcriptase (rt) Integrase: protease, genome, duplex of single stranded rna, hiv life cycle, binding and entry, hiv binds to cd4 t-cell by gp120 and gp41. Integration into host genome: dna migrates into the nucleus.

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