BILD 2 Lecture Notes - Lecture 21: Ryanodine, Skeletal Muscle, Muscle Contraction
Document Summary
Clicker question: the compound ryanodine, when present at nanomolar concentrations, keeps calcium channels on the sr constantly open. How will ryanodine affect skeletal muscle: actin binding sites will always be exposed, causing constant contraction. In living animals, you always have some atp around, but the calcium is sequestered: calcium is needed to unblock actin binding sites to allow cross bridge formation. In dead animals, membranes break down and calcium is around, but there is no more. Atp being made: the cross bridges form, but they cannot disconnect without atp. How muscle contraction ends: cross bridge cycling will continue over and over again as long as there is atp and calcium, when neural stimulation ends, calcium is pumped back into the sr and contraction ends. All individuals in a population behave alike: learned: allows individuals to change their behavior in response to their specific environment, a memory is something you"ve learned.
