PSYC 181 Lecture Notes - Lecture 13: Safrole, Designer Drug, Anorectic
Document Summary
Dat: suggest no neurotoxicity in amphetamine addicts. Methylenedioxymethamphetamine: mdma ecstasy: synthesized in 1912, 1913 patent (merck lab) Tried to develop anorectic in 1961, but dropped it because people got high. Dr. shulgin promoted this drug: street use. Also, adjunct to psychotherapy (clinical trials 1993) Illegal since 1985 (1st schedule i by dea: several analogues of designer drugs. Safrole is distilled from sassafras or nutmeg oil (>1000 doses/1 kg of safrole: effects on behavior and affect. 60-120 mg per pill (take 1-2 pills) (cid:862)death(cid:863), (cid:862)mitsu(cid:271)ishi dou(cid:271)le sta(cid:272)k(cid:863), (cid:862)killer(cid:863), (cid:862)red mitsu(cid:271)ishi(cid:863) More hallucinogenic incidence of toxic side effects much higher than mdma (narrow safety margin: mdma use. Increased from 1997-2000, but started to decline once recognized the risk: neurochemical effects. Enters neuron and causes calcium-independent release of 5-ht. Depletes forebrain 5-ht (not da: mdma and mda neurotoxicity. Can get 30% loss with single injection. No regulation of blood pressure in the brain. Could lead to cognitive deficits: amphetamine neurotoxicity.
