PSYC 181 Lecture Notes - Lecture 17: Pergolide, Monoamine Oxidase, Selegiline
Document Summary
Rate limiting step limits how much da is made, regardless of how much amino acid you have. To produce more da, skip the rate limiting step and give l-dopa, which will be converted to da, which will also increase the amount of e and ne (causes side effects like sweating and sympathetic effects) Need to prevent side effects from becoming too bad: standard treatment: levodopa (l-dopa) therapy. On/off fluctuations: only works some of the time. Dyskinesias: extra da all over the brain, not just in the caudate. Da critical in movement, so this extra da causes pain in movement. Nervousness, anxiety: anticholinergics help as well: moderate movement problems, on-off fluctuations too great with da agonists; side effects too great. Drugs used to treat parki(cid:374)so(cid:374)"s disease: anticholinergis. Improve mood; extremely difficult to treat; patients often suicidal. Miscellaneous: benztropine, biperiden, ethopropazine, procyclidine, triheyphenidyl: dopaminergic. Mao-b inhibitor (monoamine oxidase inhibitor): selegiline (boost da) Mechanism of action unknown: amantadine (increases da release)
