PSYC 2 Lecture Notes - Lecture 6: Median Toxic Dose, Choline, Blind Experiment
Document Summary
Terminal buttons have calcium channels, vesicles and transporter-recycles neurotransmitter. Resting potential: -70 mv; threshold -50 mv. Type tells if it"s inhibitory or excitatory message based on na+ or k+ ion channels open either directly or indirectly. Neurotransmitter are released and get binds to receptors of postsynaptic neuron. *chemical gradient = diffusion; electrical gradient = electrostatic pressure. Adhd: hyperactivity-impulsivity; inattention; common in kids and teens. Aka methylphenidate: inhibits reuptake of dopamine and norepinephrine. Mechanism: dopamine binds to na+ channels, causes rush in action potential, transporter brings dopamine back to presynaptic neuron. Drug mechanism: ritalin binds and blocks transporter leaves dopamine to bind and open up ion channel even more therefore postsynaptic potential stronger. Because adhd patients have more dopamine transporters than healthy so ritalin keep dopamine in extracellular space. Hyperactiveness = side effect for adhd with ritalin use because drug also affects norepinephrine. Therefore, requires optimal" level of neurotransmitter availability: prozac (depression)
