AGRI 224 Lecture Notes - Lecture 19: Dengue Virus, Viral Envelope, Japanese Encephalitis
27 Feb 2019
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Genus includes, west nile virus, dengue virus, yellow fever virus, Main proteins are m e and c proteins. The enveloped protein is really important because that"s what the immune system sees. Wanted to see how similar it was to dengue. Took samples of zika from uganda, polynesia, and brazil, and samples of dengue, west nile, yellow fever. Checked genetic code of the envelope to see how similar. How it fold determines what it looks like, and what it does overlayed dengue and zika. Difference between getting dengue and zika is one tiny place of difference. Attachment of the viral envelope protein e to host receptors mediates internalization into the host cell by apoptotic mimicry. Looks like something the cell wants to take in. Fusion of virus membrane with host endosomal membrane. The positive-sense genomic ssrna is translated into a polyprotein, which is cleaved into all structural and non structural proteins (to yield the replication proteins)
