ANFS332 Lecture Notes - Lecture 15: Viremia, Inclusion Bodies, Syncytium
27 Nov 2016
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Size: 10-300 nm (. 01-. 3 micrometers, can"t see with a light microscope. Types of viral genomes: nucleic acid: dna, rna, both dna and rna, shape: linear, circular, segmented, strandedness: ss, ds, ds and ss, sense: positive sense (+), negative sense (-), anbisense (+/-) Rna sense: positive-sense rna-viral rna with the same base sequence as mrna. Can cause infection right away; does(cid:374)"t (cid:374)eed to be part of a virion: negative-sense rna-viral rna with a base sequence complementary to that of mrna. During replication is serves as a template for the transcription of viral complementary rna (positive sense) Negative sense rna is not infectious: negative-sense rna genomes are not infectious as purified rna. These virus particles all contain a virus-specific polymerase. The first event when the virus genome enters the cell is that the (-) sense genome is copied by the polymerase, forming either (+) sense transcripts or a ds molecule.
