ANFS332 Lecture Notes - Lecture 20: Avian Influenza, 2009 Flu Pandemic, Influenza A Virus
27 Nov 2016
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Document Summary
Infection in humans typically results in various upper respiratory symptoms including. Similar symptoms with rapid onset influenza virus etiology but subsides after 2-5 days. Influenza is an infectious respiratory disease caused by rna viruses of the. Order of mononegavirales: segmented negative-sense ssrna viruses: type a influenza is most severe genus. Animal reservoir containing all known subtypes (ducks) Capable of antigenic shift (re-assortment of segments) Capable of a high rate of antigenic drift (mutations in antigenic regions: segmented negative sense rna virus (8 segments) that encode for 11 proteins. Pb2, pb1, pb1-f2, pa, ha, np, na, m1, m2, ns1, and nep: classified by surface glycoproteins hemagglutinin (ha) and neuraminidase (na) Currently 18 ha and 11 na subtypes have been identified (198 possible combinations!: exhibits quasispecies behavior (non-identical but related replicons) If 109 virions are replicated, 108 are mutants. Human seasonal influenza 2013-14: a(h1n1) and a(h3n2) A(h1n1) virus is the same virus that caused the 2009 influenza pandemic.
