BISC276 Lecture Notes - Lecture 8: Dendrite, Fluoxetine, Selective Serotonin Reuptake Inhibitor

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Can be weak or strong (mostly weak: basically electrical charge moving through a membrane, generally weak and degrades quickly, part of the nerve impulse is like standard electricity, only used over very short distances, these are very fast, action potential (=action voltage, used over long distance, local release of potential energy, all or none i. ii. Steps of neurotransmitter release: an action potential depolarizes the axon terminal, the depolarization opens voltage gated ca2+ channels and ca2+ enters the cell, calcium entry triggers exocytosis of synaptic vesicle contents, neurotransmitter diffuses across the synaptic cleft and binds with receptors on the postsynaptic cell, neurotransmitter binding initiates a response in the postsynaptic cell. Neurotransmitter action terminates when the chemicals are broken down and taken up into cells or diffuse away from the synapse: neurotransmitters can be returned to axon terminals for reuse or transported into glial cells, enzymes inactivate neurotransmitters, neurotransmitters can diffuse out of the synaptic cleft.

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