BISC306 Lecture 10: BISC306 9/25 notes
27 Sep 2017
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Document Summary
Synaptic plasticity- synapses may be the physical site at which memory is stored: new synapses may be formed and old synapses may be lost. Synaptic strength may depend on previous activity: some changes are very transient, others may be long term. Synaptic facilitation and depression: getting a more powerful signal, waves get bigger, more calcium. Habituation and sensitization in aplysia: gill withdrawal reflex habituates, noxious stimulus and sensitize reflex, reduced preparation, gives huge shock-sensitizes-tail gives big response, tail stimulus causes serotonin release from interneurons which elevates camp. camp activates protein kinase a (pka). This ultimately leads to elevated ca+2 and increased transmitter release: with repeated stimulus to the tail, increased activation of pka effects transcription and results in the growth of new synaptic connections. Neutral basis of ltp: there are 2 ionotropic receptors for glutamate called ampa and nmda receptors. Nmda and ampa: response high frequency stimulus. This causes increased insertion of ampa receptors into the membrane.
