BISC306 Lecture Notes - Lecture 5: Electrophysiology, Threshold Potential, Lipid Bilayer
14 Sep 2016
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Neurons & cell signaling: action potentials, measuring voltage difference across membranes: a. i. Measurements are usually expressed in millivolts (mv) a. ii. Resting membrane potential between -20 mv -100 mv (-65/-70) a. iii. Measured using: a recording microelectrode & reference electrode: membrane acts as a capacitor b. i. Holds charges on both sides of the membrane b. ii. Stores and separates charge on both sides, despite channels that act as resistors c. Injection of current can change membrane potential c. i. This stimulates & records a produced action potential c. ii. Deliver current & read voltage at the same time c. iii. Able to dissect system to figure out how a nerve works c. iv. Membrane can be hyperpolarized or depolarized c. iv. 1. c. iv. 2. Depolarized-making the cell less negative; causes action potential: stimulating a cell to create an action potential d. i. When an excitable tissue reaches the threshold potential, an action potential is generated: reaching threshold potential e. i.
