NTDT200 Lecture Notes - Lecture 8: Pernicious Anemia, Rhodopsin, Hemoglobin

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Kimani the gorilla: dying from vitamin d deficiency, has rickets, bone malformation and muscle weakness treated with tenfold the normal dose of vitamin d supplementation. Individual units: bioavailability-how well a nutrient is absorbed and utilized by the body, solubility determinant of absorption and transportation process, affects where they are stored and risk for toxicity, fat-soluble-a,d,e,k, water soluble-b vitamins, choline and vitamin c. Vitamin d: sunshine vitamin, made in skin, from cholesterol and uv light, not enough sun exposure makes it essential to consume in diet, activated in the kidneys and liver. Functions: acts as a hormone, helps bone growth and maintenance, regulates calcium, regulates calcium, regulates protein synthesis, possibly regulates cardiovascular function. Activation: calcitriol: fully activated form from the kidney. Regulation of blood calcium: calcitriol increases absorption of calcium in the intestine, active vitamin d and parathyroid hormone decrease calcium excretion by the kidneys.

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