NTDT401 Lecture Notes - Lecture 12: Glycogen, Thiamine, Steroid Hormone Receptor
20 Dec 2016
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Pnp, plp and pmp cannot be absorbed (phosphate group) Phosphorylated vitamers must be dephosphorylated before absorption. By enterocyte: pn to pnp pyridoxine kinase (atp dependent, pl to plp kinase (at dependent, pnp to plp pmp and pnp oxidase (fmn dependent, plp to pl phosphatase. Purpose of transamination form non essential amino acids: or funnel them into glutamate so glutamate can be deaminated. Gaba synthesis; neurotransmitter in brain helps sleep. Serotonin/melatonin; neurotransmitter helps sleep/excitatory: ****gaba synthesis, serotonin, melatonin. Cysteine & methionine have sulfur; get rid of sufur and rely on b6. Plp used in metabolizing amino acids and transfer from one to the other. Cleavage serine to glycine: plp remove methyl group from serine, transfer to thf (folate, 5-10-ch2-thf and glycine produced, metabolizing/making coenzyme form for folate important for new cell/dna making. Synthesis: plp involved in making a lot of critical compounds. Glycogen degradation to store cho: plp required for phosphorylate glycogen to form g-1-p (get glucose)
