PSYC314 Lecture Notes - Lecture 5: Positron Emission Tomography, Diffusion Mri, Ct Scan
29 Aug 2016
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Histological methods: fixative- chemical such as formalin; prepares tissue, microtome- instrument that produces think slices, perfusion- animal"s blood replaced by fluid like saline solution or a fixative. Specific wavelengths are then capable of altering the membrane potential. Chr2 ion channels- photosensitive protein channels which depolarize the membrane when blue light is presented by introducing na+ Nphr ion transporter- channel that hyperpolarizes the membrane when yellow light is presented by introducing cl- Radio frequency (electrolytic) lesion- alternative current of very high frequency capable of destroying neural tissue. Excitotoxic lesion- drill hole; intracerebral injection of excitatory amino acid such as kainic acid. Kainic acid- neurotoxin; produces excitotoxic lesions by stimulating neurons to death. Transcranial magnetic stimulation- stimulation of cerebral cortex by means of magnetic fields produced by passing pulses of electricity through a coil of wire placed next to skull. Targeted mutations- mutated gene produced in lab and inserted into chromosomes; fails to produce a functional protein.
