BSC 2010 Lecture Notes - Lecture 7: Pyruvate Dehydrogenase Complex, Malate Dehydrogenase, Citric Acid Cycle

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9/18 lecture 12: chapter 6: pathways that harvest and store chemical energy: nad+- oxidizing agent nadh- reducing agent, glucose- after glycolisis- pyruvate(3 carbons) and 2 nadp, 2 nadh. Energy: cellular respiration, pyruvate oxidation: requires oxyten, multistep reaction by pyruvate dehydrogenase complex (60 proteins and. Malate- malate dehydrogenase- oxaloacetate: convert nadh to atp: nadh is oxidized. Electrons go thru oxygen, produce water, proton ions get pumped up to form a gradient. The gradient thru chemiosmosis and makes atp: krebs cycle won"t work without pxygen because it needs to produce water in electron transport chain. Concept 6. 3: carbohydrate catabolism in the absence of oxygen releases a small amount of energy: under anaerobic conditions, nadh is reoxidized by fermentation, there are many different types of fermentation, but all operate to regenerate. Nad: the overall yield of atp is only tow- the atp made in glycolysis, c6h12o8+ 2adp +2p---> 2 ethanol +2co2 +2atp, cellular respiration is a major catabolic pathway.

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