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Lecture 27

CHM 3218 Lecture Notes - Lecture 27: Aconitase, Integral Membrane Protein, Flavin Mononucleotide


Department
Chemistry
Course Code
CHM 3218
Professor
Stewart Jon
Lecture
27

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as
isocitrate dehydrogenase (IDH )over
coi 'ew.at
ia
on #'oi d
+
monitor
'Ia*oI
+NAD
't
oy W
'05
+ NADH state
OH If carbon
isocitrate
ketogtutarak (x-KG )
Review
i¥d%0J
To +coz
d- ketoafid decarboxylation
ALWAYS requires TPP to stabilize (arbanion
00O
""a
Ahoy /¥€ +co .
p-ketoacid decarboxylation (No co -factor needed)
Thus if d- Veto acid TPP
if p-Ketoacid -9 No cofactor Napt needed to transport e-
0
Ozc ¥0
'
%fo\~c°z
'
dA-Bt
,Rypr p7
'
°
'#(9- + coz t NADH
at
"0
'D ,*E°
¥¥
"
0YB :
An
"
/,Y
NHZ
¥
0
R
d- ketoglutarate dehydrogenase
5
NAD+yNADH
"
"
¥¥%
=
aas ##,+ E
oz (same mechanism as pyruvate dehydrogenase)
+\
,veto and
W
Coast requires carbon 4was
TPP oxidized
Addihb@ators-TPP-Lipoamide-FADSuclinyl-CoAsynthetaselIncoisuccinicAa.d
)
nastier
"
%IHEB ZHEB
waves active
(OAS ~\
(oi tPi + Gdp =-o.cn/c0it6TPtCoAsH site to mum
THE ---
Thngnpptr
succinate )-B-H11 )-B- H
yFHM
#:] +B- A
-0^1
0H.o
41 4
11 GTP
coasfnoi coastonoi
EgII@noitoEnsGFItofkogoyfo.y
;IT
-
to -
other,
.ru/oYY
.*
OYY.
tait
tB- H
NOTE :Y-phosphate
stereochemistry
overall retention
since 2 nucuophillk
attacks
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