BIOL 3310 Lecture Notes - Lecture 7: Macrophage, Ontogeny, Antiparasitic
LymphaticOrganization
Thymus gland (primary lymphatic pipe organ )
-Very large in fetus (don't have a strong immune system)-After age 14, intricacy (shrinkage ) begins-In
elderly, mostly composed of fatty and fibrous tissue paper
Natural Active voice Resistance
Produces computer memory cells-production of one's own antibodies or T cells as a final result of
infection or natural exposure to antigen *getting the infection/illness
Failing T cell Test
1. Inability to recognize the reitculoendothelial cells -incapable of recognizing a foreign attempt on the
body2. Reacting to the self-antigen-T cells would attack one's own tissue paper , causing autoimmune
disease
Antigen Processing
-APC encounters antigen-Internalizes it by endocytosis-Digests it into molecular shard -Video display
relevant fragments (epitope ) in the channel of the MHC protein
Reticular Cells
-Branched stationary cells that contribute to the stroma of lymphatic organs-Act as APCs in the thymus
Pathogenic
Disease-causation
Lymphatic tissues
composed of totality of lymphocyte and macrophage that populate many organs in the body
When helper T cell recognizes Ag -MHC complex:
-Secrete interleukins that exert ternion effect :1. attract neutrophils and NK cells2. attract macrophages,
stimulate their phagocytic action , and inhibit them from leaving the area3. stimulate T and B cell
mitosis and maturation
Membrane Attack Complex
Complement proteins descriptor ring in blood plasma membrane of target cell causing cytolysis
Immunodeficiency
Immune system fails to react vigorously enough
Clonal selection of B cellular telephone
mitosis = USA of identical B cells against the same antigen -Most differentiate into plasma cells
(antibody mill )
Recognition (Humoral Resistance ) (2)
-Immunocompetent B cubicle has thousands of surface receptor for one specific antigen Activation
Menachem Begin when an antigen bind to several of these receptors:-inter-group communication them
together-taken into cell by receptor-mediated endocytosis-Displays foreign antigen on MHC-II
Lymph atic nodules (follicles)
-Dense masses of lymphocytes & macrophage that congregate in response to pathogens-Lymph nodes,
palatine tonsil & appendix-Peyer patches: dense clusters in the ileum
Dendritic Cells
-Branched, mobile APCs found in epidermis, mucous membranes, and lymphatic organs-Alerting
immune system to pathogens that have breached their aerofoil
How are T jail cell tested in the Genus Thymus ?
Reticuloendothelial cells in the thymus test T cells by presenting self-antigens to them
Interferons
polypeptide secreted by cellphone invaded by viruses 1. antiviral effect2.anticancer effect
Secondary coil Lymphatic Electronic organ
Lymph nodes, tonsils & spleen-immunocompetent cells populate these tissues
Humoral (antibody -mediated) immunity: B CELLS
-Mediated by antibody that do not directly destroy a pathogen -Indirect attack where antibodies
neutralize the pathogen-Can only body of work against the extracellular stage of infectious
microorganisms
-itis
suffix denotes inflammation of specific organs
Lymphatic Capillaries
Closed at one endTethered to tissue by protein fibril
Mobilization of Defenses
Most immediate requirement for dealing with tissue harm is to get the defensive WBC to the site quickly
Local hyperemiaVasoactive chemicals dilate local ancestry vessels
Elephantiasis
Blocked lymph watercraft caused by filial worm which accumulates in stage . This is caused by
mosquitos and leads to edema or fluid chassis up.
3 degree of humoral and cellular immunity
1. Recognition2. Attack3. Retentiveness
Humoral Attack
1. Neutralization2. Complement fixation3. Agglutination4. Precipitation
Lingual faucial tonsil
Pair at the root of knife
Monocytes
Movement from blood into continuative tissues & transform into macrophages
Cytokines
Socio-economic class of chemicals that regulates inflammation and immunity-secreted by leukocytes-
Include interferon , interleukins, tumor mortification factor, chemotactic factors
Natural passive exemption
through placenta, milk-fetus or infant acquires antibodies from mother-temp
Determinant
Antigenic determinants
Effects of Reye Syndrome
-Swelling of brain neurons-Fatso infiltration of liver and other viscera-Imperativeness of swilling brain
Fever
Defense mechanism that can do more good than harm-promotes interferon activity-accelerates
metabolic rate & tissue paper repair-inhibits pathogen reproduction
Document Summary
Very large in fetus (don"t have a strong immune system)-after age 14, intricacy (shrinkage ) begins-in elderly, mostly composed of fatty and brous tissue paper. Produces computer memory cells-production of one"s own antibodies or t cells as a nal result of infection or natural exposure to antigen *getting the infection/illness. Failing t cell test: inability to recognize the reitculoendothelial cells -incapable of recognizing a foreign attempt on the body2. Reacting to the self-antigen-t cells would attack one"s own tissue paper , causing autoimmune disease. Apc encounters antigen-internalizes it by endocytosis-digests it into molecular shard -video display relevant fragments (epitope ) in the channel of the mhc protein. Branched stationary cells that contribute to the stroma of lymphatic organs-act as apcs in the thymus. Lymphatic tissues composed of totality of lymphocyte and macrophage that populate many organs in the body. When helper t cell recognizes ag -mhc complex:
