ANSC 452 Lecture Notes - Lecture 2: Myosin, Protein Kinase A, Protein Kinase
15 Nov 2020
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> intiation > recognize 5" cap; gather mrna, erna & ribosomes sinitiation factors are eies (eukaryotic lortation factors) Pabp binds to poly-t tail of mrna makes loop shape. Elf4a helicase (breaks helices) assembles ribosome and brings everthing together. " always occuring in cells, but be at different rates may. Yae- bp interferes with assembly because it binds to eifae at the same place as elf 4g, which stops assembly. 4 can be phosphorylated xa by mtor which prevents binding to e ifa e, which allows e ifa to bind to elfae. Mtor serine kinase inhibits rapamycin to heets initiation of protein synthesis, encourages ribosomes to assemble, which encourages translation. How did protein kinase a result in expression of tetal myosin heavy chain isoforms? eithe to phosphorylation! of transcription factur) protein synthesis mtor. 2 aa/second in eukaryotes teef18 e e fz control the speed.
