BIOL 300 Lecture Notes - Lecture 22: Exon, Endonuclease, Eif2
16 Dec 2017
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Document Summary
Global translational regulation > important in lacking food supplies! In contrast, mtorc1 is inactive when bound by a complex of rheb associated with gdp (lower right). Consequently, they leave a higher fraction of cellular rheb in the gtp conformation that activates mtorc1 protein kinase activity: low nutrient concentrations also regulate rheb gtpase activity by a mechanism that does not require tsc1/ tsc2. Active mtorc1 phosphorylates 4e-bp, causing it to release eif4e, stimulating translation initiation. In the absence of mtorc1 activity, all of these processes are inhibited. In contrast, activated mtorc1 inhibits autophagy, which is stimulated in cells with inactive mtorc1. The tor -/+ : less translation, might develop smaller, and has a long-lived phenotype. When tor is active, it adds a lot of phosphates to 4e-bp > makes it hyperphosphorylated and decreases its affinity to eif4e. This ramps up translation by the association of elf4e with both capped mrna and elf4g.
