MCB 150 Lecture Notes - Lecture 29: Phagolysosome, Phagocytosis, Phagosome
6 Apr 2017
School
Department
Course
Professor
Document Summary
Eu cells could have a few or hundreds of these single membrane bound organelles. Heavy artillery i. e. get rid of a bacterial phage. Other things like proteases will degrade small things. Only found in lysosomes (if found anywhere else, they may cause problems by degrading things that should not be degraded) These hydrolases are only active at a ph of 5 (which is the ph in the lysosome) If the cell bursts, the hydrolases will be inactive in the cytoplasm (ph 7) Protons are pumped into the lys through a channel that requires atp. Get rid of sulfurs (especially in nuc acid) Thing binds to a receptor protein and enters the cell via endocytosis. Receptor mediated endocytosis brings things into the cell in an endocytic vesicles. This becomes larger by adding other similar vesicles into an early endosome (has a smaller ph) There aren"t any hydrolases in there anyway at this point.
