MCB 150 Lecture Notes - Lecture 35: Chromatin, Nuclear Localization Sequence, Lipid Bilayer

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04/22: list the stages of m-phase and describe the events occurring in each stage, explain the breakdown and reformation of the nucleus during mitosis, compare and contrast anaphase a and anaphase b. Spindle apparatus begins to form, and polar microtubules overlap each other: prometaphase: nuclear envelope disintegrates. Microtubules attach to the kinetochores of chromosomes and being moving them to the middle of the spindle: metaphase: all chromosomes are positioned in the middle of the spindle. The spindle is anchored to the cell membrane by astral microtubules: anaphase: sister chromatids are pulled apart by the disassembly of kinetochore microtubules at the kinetochore. The spindle poles are moved farther apart to fully separate the replicated chromosomes: telophase: daughter chromosomes are fully separated and are clustered at opposite poles of the spindle. Nuclear envelope forms around each set and the chromosomes de-condense. In most cells, mitosis is followed by cytokinesis division of all cell contents.

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