MCB 300 Lecture Notes - Lecture 36: Corynebacterium Diphtheriae, Diphtheria Toxin, Signal Peptidase
25 Apr 2019
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Lecture 36: pathogenic microbe-host interactions-x: fantastic effectors and where to find. Delivering the goods: the importance of virulence factor delivery. - in order to deliver their virulence factors, bacteria must have mechanisms for targeting and secreting the proteins to the host or extracellular environment. - thus, secretion of virulence factors is itself a virulence determinant (property) of pathogenic bacteria. Importance take home message: secretion of virulence factors is itself a virulence determinant (property) of pathogenic bacteria. Without an effective means of selectively delivering virulence factors to the proper host environment, bacteria cannot exert their virulence properties, and therefore are not pathogenic. Without an effective means of selectively delivering virulence factors to the host environment, bacteria are not pathogenic. - secretion machines/systems solve the the biophysical problem of how to move a hydrophilic/charged biopolymer across a hydrophobic barrier from inside a cell to a new environment. - multiple secretion machines exist, which are finetuned for the specific protein cargo:
