MCB 300 Lecture Notes - Lecture 35: Small Molecule, Peptidoglycan, Microorganism

• School: University of Illinois
• Department: Molecular and Cell Biology
• Course: MCB 300
• Professor: C Vanderpool

Document Summary

Lecture 35: pathogenic microbe-host interactions- ix: remodeling the host into. The supremacy of bacterial toxins as virulence factors. Most pathogenic bacteria produce and secrete/deliver bacterial toxins and effectors, that act upon host cells and tissues in such a manner as change their fundamental properties in a manner that benefits the pathogen. - allow bacterium to access to host cell nutrients. - allow bacterium to passage through host tissues. - allow bacterium to avoid detection by host innate immune sensing mechanisms. Toxins were once thought to be the only virulence factors produced by pathogenic bacteria. - first discovered and characterized (because they are secreted away from the bacterium) - generally act independently from the bacterium. - led to the long held belief of the supremacy of toxins as the. Endotoxins small molecules generally associated with microbes, then when released from the microbe, are sensed to generally cause a pro-inflammatory reaction.