MCB 150 Lecture Notes - Lecture 27: Sister Chromatids, Dynein, Cytokinesis

• School: University of Illinois
• Department: Molecular and Cell Biology
• Course: MCB 150
• Professor: B Mehrtens

Document Summary

Late during prophase, the nuclear envelope breaks down and disappears (for microtubules to get access to the chromosomes inside the nucleus): Gets phosphorylated (kinase in prophase) not hydrolyzed just lose affinity to its neighbor. Lamins b = integrated into the inner membrane of nuclear envelope stay bound to vesicles. Nuclear envelope reforms prior to chromosome decondensation during telophase: Dephosphorylation (phosphatases) remove phosphate group from biological molecules. Regain affinity they have prior to prophase heterochromatin attached nuclear envelope via nuclear lamina. Chromatin decondensed euchromatin + heterochromatin reform nucleoli histone protein + nuclear lamin protein + dna polymerase + rna polymerase need to get back to nucleus with nls (never gets chopped off) Astral microtubules move towards the cell membrane in the closet edge. Kinetochore microtubules move towards the middle of the cell reach kinetochore of sister chromatids important for prometaphase move chromosomes back and forth until reaching metaphase plate.