BIOS 222 Lecture Notes - Lecture 2: Protein Phosphatase 2, Metastasis, Pd-L1
Document Summary
Allergy hypersensitivty - ige was discovered in 1966. Allergy as a physiologic defense against noxious agents. Allergy as an irritant reduction, toxin expulsion, and a barrier modulation response when noxious agents gain access. Barrier regulation hypothesis of allergic sensitization to food. Igm gene splicing was one of the first to be discovered to do that. Simple reflex to axon-axon immune reflex to inflammatory reflex to enteric tissue projective reflex. Pain is one of the four cardinal sligns of inflammation -> pain, heat, vasodialation (redness), swelling (edema). Nociceptor neurons innervate barrier tissues so pain is a protective response. Chronic pain affects 20% of the population and it persists long after healing. Bacteria count is highest at the highest level of pain. Neuro-immunology in host defense with pathogen interaction with nervous system. Targeting of inhibitory receptors on t cells for the treatment of cancer. Pd-l1 frequently expressed on tumors and pd-1 usually on the t cell.
