CHEM 233 Lecture Notes - Lecture 4: Ground Glass Joint, Molecularity, Nucleophilic Substitution
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Preparation of alkyl halides by nucleophilic aliphatic substitution. As shown in figure 1, nucleophilic aliphatic substitution reaction involves the conversion between different functional groups in which nu: represents a nucleophile and l: represents a leaving group. The nonbonding pairs of electrons on the nucleophile are donated to an electrophilic atom which results in the formation of a new covalent bond during the process of substitution reaction. This reaction is like a lewis acid-base reaction in which the electrophilic carbon atom acts as a lewis acid and nucleophile acts as a lewis base. The leaving group may be neutral or negatively charged and must accept the pair of bonding electrons from the carbon atom when the c-l bond breaks. Thus, the rate of substitution reaction depends on the leaving ability of a particular group l: if the better the leaving group is better at leaving the substance, the faster the reaction will occur.
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