BIO 152 Lecture Notes - Lecture 11: Adenylyl Cyclase, Protein Kinase A, Amyotrophic Lateral Sclerosis
16 Apr 2017
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Document Summary
Scientists at uc, riverside developed an exogenous agonist of the receptor. Mice with mutated epha4 showed increased survival and decreased neuron degeneration when given the drug. When no ligand is present, the g protein is inactive. When the ligand binds, the gdp replaced by gtp, which leads to an activated g protein. Part of the g protein is released to bind to another protein. Activated subunit binds to and activated target protein. Example: activated adenylyl cyclase converts atp into the second messenger camp, which in turn activates protein kinase a, activated proteins kinase. First messenger changes the shape of the receptor. Part of the protein is released from receptor and connects to enzyme. Enzyme becomes active, produces lots of a second messenger. Each activated receptor activates multiple g proteins which in turn activates adenylyl cyclase enzymes. Each adenylyl cyclase enzyme produces large amounts of the second messenger camp, which activates many molecules of protein kinase a.
