BIOLOGY 225 Lecture Notes - Lecture 3: Paracrine Signalling, Cell Membrane, Proopiomelanocortin

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15 Jan 2017
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Components of endocrine system (step-by-step: production organ (endocrine, transport medium (blood, target organ (receptors) Synthesized in rough er stored in vesicles. Made and stored in endocrine cell; made in continuous basis. Released by exocytosis; most are hydrophilic: dissolve in aqueous medium, cannot pass through plasma membrane. Bind to transmembrane receptors on target cell. Hydrophobic: insoluble in aqueous medium, diffuse through plasma membrane. July 5, 2016: can"t be stored; synthesized on demand only made once stimulus arrives, transported to target cell by carrier proteins, bind to intracellular receptors. Steroid hormone transport (simple diffusion; hydrophobic molecules: hormone secretion (binding proteins) target tissue (hormone-receptor binding) receptor activation . Biological action: solubility in aqueous medium (see above, synthesis & secretion (see above, transport, receptor binding. Characteristics of hormone actions: produced in small quantities, large effects message amplification, diverse biological actions. Many backups for lack of 1 hormone not functioning properly. Hormone receptor interactions: one hormone may bind to multiple receptors.

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