MCDB 423 Lecture Notes - Lecture 4: Hindbrain, Transfection, Antigen

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purplebeaver856

5 May 2017

School

U of M

Department

Molecular, Cellular and Developmental Biology

Course

MCDB 423

Professor

John Kuwada

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Document Summary

Fo(cid:396) do(cid:396)sal (cid:448)e(cid:374)t(cid:396)al a(cid:454)is fo(cid:396)(cid:373)atio(cid:374), (cid:449)e"(cid:396)e goi(cid:374)g to look at the (cid:448)e(cid:396)te(cid:271)(cid:396)ate"s spi(cid:374)al (cid:272)o(cid:396)d. Neurons first on the dorsal side of the spinal cord. Commissural neurons produce axons down to the ventral median of the spinal cord. Can be assayed by morphology and molecular markers. Motor neurons are found on the ventral half. They project their axons out to innervate muscles. They can be assayed by morphology and molecular markers. There are two non neural cell types that are in the pattern of the dorsal ventral axis and are both quite important for the formation of the pattern. These are the roof plate cells (not neurons, can be assayed by morphology and molecular markers) On the opposite side are the floor plate neurons which can be assayed by morphology markers and functional assay. There is a mesodermal structure the notochord which is derived from the dorsal mesoderm.

Related Questions

Nerve cells that conduct messages are called (1) ____. (2) _____ cells, which support and nurture the activities of neurons, make up less than half the volume of the nervous system. (3) _______ neurons respond to specific kinds of environmental stimuli, (4) ______ connect different neurons in the spinal cord and brain, and (5) ______ neurons are linked with muscles or glands. All neurons have a (6) _______ ________ that contains the nucleus and the metabolic means to carry out protein synthesis. (7) _______ are short, slender extensions of the (6), and together these two neuronal parts are the neuronsâ âinput zoneâ for receiving (8) _____. The (9) _____ is a single long, cylindrical extension away form the (10) ______; in motor neurons, the (11) ______ has finely branched (12) ________ that terminate on muscle or gland cells and are âoutput zones,â where messages are sent on to other cells. A neuron at rest establishes unequal electric charges across its plasma membrane, and a(n) (13) ____ ____ is maintained. Another name for (13) is the (14) _____ _____ _____; it represents an ability for the membrane to be disturbed. Weak disturbances of the neuronal membrane might set off only slight changes across a small patch, but strong disturbances can cause a(n) (15) _______ ______, which is an abrupt, short-lived reversal in the polarity of charge across the plasma membrane of the neuron. For a fraction of a second, the cytoplasmic side of a bit of membrane becomes positive with respect to the outside. The (16) ______ that travels along the neural membrane is nothing more than short-lived changes in the membrane potential. A. Neurons H. Sensory B. Motor I. Endings C. Interneurons J. Disturbance D. Cell body K. Signals (stimuli) E. Axon L. Voltage differential F. Dendrites M. Resting membrane potential G. Neuroglial N. Action potential

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#1 Visceral sensory information enters the CNS on afferent fibers within

A) dorsal roots S_2 to S_4.

B) dorsal roots T_1 to L_2.

C) cranial nerves V, VII, IX, and X.

D) both B and C

E) A, B, and C

#2 Which of the following is not a function of the neuroglia?

A) support

B) memory

C) phagocytosis

D) secretion of cerebrospinal fluid

E) maintenance of blood-brain barrier

#3 Mary is in an automobile accident and suffers a spinal cord injury. She has lost feeling in her lower

body. Her doctor tells her that swelling is compressing a portion of her spinal cord. Which part of

her cord is likely to be compressed?

A) the anterior gray commissures

B) the anterior white commissures

C) the anterior gray horns

D) ascending tracts

E) descending tracts

#4 The efferent division of the peripheral nervous system innervates:

A) skeletal muscle cells

B) glandular cells

C) smoothmusdecells

D) heart muscle cells

E) all of the above

#5 Cerebrospinal fluid flows within the

A) pia mater.

B) dura mater.

C) filum terminale.

D) arachnoid mater.

E) subarachnoid space.

#6 A patient develops a tumor of a cranial nerve that leads to difficulty in speaking from a loss of

tongue movement.which cranial nerve is affected?

A) glossopharyngeal

B) vagus

C) spinal accessory

D) hypoglossal

E) trigeminal

#7 Parkinson disease is the result of

A) inadequate production of dopamine by substantia nigra neurons.

B) inadequate production of GABA by neurons in the basal nuclei.

C) weak response of the red nuclei of the mesencephalon.

D) decreased levels of acetylcholine from neurons in the substantia nigra.

E) hyperactivity of the limbic system.

#8 Based on the motor homunculus, which of the followingbody regions has the largest motor units?

A) larynx B) hands C) tongue D) face E) back

#9 If the corpus callosum is surgically cu!

A) conscious decisions are made without regard to sensations from the left side.

B) objects toudred by the left hand can be recognized but not verbally identified.

C) symptoms of the "disconnection syndrome" appear.

D) the two cerebral hemispheres operate independently.

E) all of the above

#10 The flexor reflex

A) moves a limb away from a painful stimulus.

B) is an example of a monosynaptic reflex.

C) prevents a musde from generating damaging tension.

D) usually depends on cranial neurons.

E) prevents a muscle from overstretching.

#11 The subdural space lies between

A) the dura mater and the arachnoid mater.

B) the arachnoid mater and the pia mater.

C) the endosteum and the periosteum.

D) the pia mater and the dura mater.

E) the pia mater and the subarachnoid space.

#12 _____ is a condition resulting from an inflammation of a facial nerve.

A) Cerebral palsy

B) Addison disease

C) Bell palsy

D) any of the

#12 Clusters of RER and free ribosomes in neurons are called

A) microglia.

B) neurofilaments.

C) neurofibrils.

D) Nisslbodies.

E) perikaryon.

#1 Visceral sensory information enters the CNIS on afferent fibers within

A) dorsal roots 52 to 54.

B) dorsal roots T1 to L2.

C) cranial nerves V VIL DC and X.

D) bothB and C

E) a, n, and C

#2 Which of the following is not a function of the neuroglia?

A) support

B) memory

C) phagocytosis

D) secretion of cerebrospinal fluid

E) maintenance of blood-brain barrier

#3 Mary is in an automobile accident and suffers a spinal cord injury. She has lost feeling in her lower

body. Her doctor tells her that swelling is compressing a portion of her spinal cord. Which part of

her cord is likely to be compressed?

A) the anterior gray commissures

B) the anterior white commissures

C) the anterior gray horns

D) ascending tracts

E) descending tracts

#4 The efferent division of the peripheral nervous system innervates:

A) skeletal muscle cells

B) glandular cells

C) smoothmusdecells

D) heart muscle cells

E) all of the above

#5 Cerebrospinal fluid flows within the

A) pia mater.

B) dura mater.

C) filum terminale.

D) arachnoid mater.

E) subarachnoid space.

#6 A patient develops a tumor of a cranial nerve that leads to difficulty in speaking from a loss of

tongue movement. IA/hich cranial nerve is affected?

A) glossopharyngeal

B) vagus

C) spinai accessory

D) hypoglossal

#7 Parkinson disease is the result of

A) inadequate production of dopamine by substantia nigra neurons.

B) inadequate production of GABA by neurons in the basal nuclei.

C) weak response of the red nuclei of the mesencephalon.

D) decreased levels of acetylcholine from neurons in the substantia nigra.

E) hyperactivity of the limbic system.

#8 Based on the motor homunculus, which of the followingbody regions has the largest motor units?

A) larynx B) hands C) tongue D) face E) back

#9 If the corpus callosum is surgically cu!

A) conscious decisions are made without regard to sensations from the left side.

B) objects toudred by the left hand can be recognized but not verbally identified.

C) symptoms of the "disconnection syndrome" appear.

D) the two cerebral hemispheres operate independently.

E) all of the above

#10 The flexor reflex

A) moves a limb away from a painful stimulus.

B) is an example of a monosynaptic reflex.

C) prevents a musde from generating damaging tension.

D) usually depends on cranial neurons.

E) prevents a muscle from overstretching.

#11 The subdural space lies between

A) the dura mater and the arachnoid mater.

B) the arachnoid mater and the pia mater.

C) the endosteum and the periosteum.

D) the pia mater and the dura mater.

E) the pia mater and the subarachnoid space.

#12 _____ is a condition resulting from an inflammation of a facial nerve.

A) Cerebral palsy

B) Addison disease

C) Bell palsy

D) any of the

#12 Clusters of RER and free ribosomes in neurons are called

A) microglia.

B) neurofilaments.

C) neurofibrils.

D) Nisslbodies.

E) perikaryon.

MCDB 423 Lecture Notes - Lecture 4: Hindbrain, Transfection, Antigen

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